In this ongoing collaboration with Antonio Sanz-Clemente at Northwestern University, we define an additional mechanism regulating the synaptic expression of the GluN2B subunit of NMDA receptors. Following synaptic activity, the GluN2B subunit is phosphorylated on the C-terminal PDZ ligand at
In this collaboration with the Swanson lab at UCSF, we show that NMDA-mediated superoxide production requires both a source of calcium influx and agonist binding to the glutamate site of the NMDA receptor (GluN2B subunit to be specific). Thus, both
MK801 is an open-channel blocker of the NMDA receptor pore. That is, when the receptor is activated and the channel opens, MK801 enters the pore and blocks it. Usually, MK801 is used extracellularly, but multiple studies have included it in
Not just passed, apparently she destroyed it! Congrats to PhD Candidate Eden Barragan!
Exciting new collaborative publication with David Olson’s lab on the possibility that psychedelics may be rapid-acting antidepressants. Was fun to get back into studying 5-HT2A receptors after a long hiatus. Covered by the press: UC Davis LA Times Newsweek New
After initial learning, subsequent learning is independent of NMDA receptor function, but requires mGluRs and increases in intrinsic excitability. New publication in collaboration with the Wiltgen Lab. https://www.ucdavis.edu/news/how-experience-changes-basics-memory-formation/
Excited to see the lab’s first original research publication in print and congrats to Jon Wong for his first scientific publication! It was even a featured article. PDF can be found here.
Shekib comes to us from Tom O’Dell’s lab at UCLA where he found unique NMDA receptor differences between ventral and dorsal hippocampus mediated by SK channels that account for differences in synaptic plasticity between those regions. We’re excited to have
We are excited to have MD/PhD student Ariel Jacobi rotating in the lab. As an undergraduate, Ariel worked with David Lynch at UPenn examining the novel possibility of postsynaptic D-serine and its biosynthetic enzyme, serine racemase. She then spent a
Jon presents his poster “Postsynaptic serine racemase regulates NMDA receptors” at this year’s Society for Neuroscience (SfN) meeting in Washington, DC. His poster drew a good audience including multiple luminaries in the field (e.g. Jon Johnson, U Pitt, seen here).