Excited to announce the launch of the UC Davis Institute for Psychedelics and Neurotherapeutics Announcement: https://www.ucdavis.edu/health/news/uc-davis-establishes-institute-psychedelics-and-neurotherapeutics Website: https://neurotherapeutics.ucdavis.edu/
Congratulations to Dr. Barragan!
Huge congrats to Eden Barragan who presented her dissertation exit seminar today entitled “D-serine is a Determinant of Non-Ionotropic LTD” on a project that she initiated during the COVID19 pandemic with some incredibly cool results we cannot wait to share.
Increased excitation-inhibition balance and a loss of GABAergic synapses in the serine racemase knockout model of NMDA receptor hypofunction
Congrats to Shekib for his first Gray Lab publication! There is substantial evidence that both NMDA receptor (NMDAR) hypofunction and dysfunction of GABAergic neurotransmission contribute to schizophrenia, though the relationship between these pathophysiological processes remains poorly understood. Here, we used
NeuroFest 2021 talk
I enjoyed giving a virtual public talk at NeuroFest 2021 entitled: “Reversing Synapse Dysfunction in Neuropsychiatric Disease” Watch it here, my talk begins at 38:15
Postsynaptic serine racemase regulates NMDA receptor function
Congrats to Jon Wong for his first-author publication in the Journal of Neuroscience – and the cover of the final ever print issue! D-serine is the primary NMDA receptor (NMDAR) co-agonist at mature forebrain synapses and is synthesized by the
First Gray Lab graduate! Dr. Jon Wong
Biggest congratulations to new Ph.D. recipient Jon Wong who presented his dissertation exit seminar today. Unfortunately it had to be over Zoom due to COVID-19 so we could not all celebrate in person, but Jon did a great job. Hope
Postsynaptic serine racemase regulates NMDA receptor function – BioRxiv Preprint
D-serine is the primary NMDA receptor (NMDAR) co-agonist at mature forebrain synapses and is synthesized by the enzyme serine racemase (SR) in neurons, though the localization of D-serine release is unknown. Here, we show that SR is postsynaptic and, using
Welcome Hannah Saeger
The Gray Lab welcomes Hannah Saeger who rotating in the lab from the Pharmacology/Toxicology graduate group. She graduated from UC Santa Cruz where she worked in a C. elegans laboratory examining the regulation of gene expression during development, specifically the
Gray Lab at SfN2019
We all went to a reception at the Willis Tower in Chicago during the 2019 SfN meeting.
Parallel non-ionotropic and ionotropic requirements for NMDA-mediated superoxide production
In this collaboration with the Swanson lab at UCSF, we show that NMDA-mediated superoxide production requires both a source of calcium influx and agonist binding to the glutamate site of the NMDA receptor (GluN2B subunit to be specific). Thus, both