Gray JA, Zito K, and Hell JW (2016). Non-ionotropic signaling by the NMDA receptor: controversy and opportunity. F1000Research, 5(F1000 Faculty Rev): 1010.

Figure 1-3

In collaboration with Karen Zito and Johannes Hell, I recently reviewed the emerging literature on possible non-ionotropic signaling by the NMDA receptor, which is classically a ligand-gated ion channel.  This conformational-based signaling remains controversial but, if validated, could open the doors for a new era of understanding ion channels and synapse function.

New review article on non-ionotropic NMDA receptor signaling