I am really excited to Meaghan joining the lab, my first postdoc!  She comes from Gabriela Popescu’s laboratory at the University at Buffalo, where she published a series of elegant studies that contributed significantly to our understanding of the structure/function relationships within the NMDA receptor through detailed single-channel analysis. Meaghan’s work described how bupivacaine, a local anesthetic that is primarily a sodium channel blocker, also acts as an antagonist at NMDA receptors and, thus, may have some benefit in preventing the central sensitization that causes chronic pain. In addition, she published work describing how closure of the agonist binding clefts on the NMDA receptor relate to agonist efficacy. Her publications can be found here.  Welcome Meaghan!

Meaghan Paganelli, PhD joins the Gray lab!