John A. Gray, MD PhD
B.S. in Biochemistry, Case Western Reserve University
Ph.D. in Biochemistry, Case Western Reserve University
M.D., Case Western Reserve University School of Medicine
Residency in Psychiatry, University of California, San Francisco
Postdoctoral Fellowship, University of California, San Francisco
I am interested in understanding the molecular and cellular mechanisms involved in synapse function and plasticity and how these processes may be disrupted in neurological and psychiatric disorders. I earned my PhD in the laboratory of Bryan Roth at Case Western Reserve University (now at UNC) examining the mechanisms underlying the desensitization and downregulation of serotonin 5-HT2A receptors. Then, during my clinical training in psychiatry at the University of California, San Francisco, I became interested in the synaptic basis of neuropsychiatric disorders and pursued postdoctoral research in the laboratory of Roger Nicoll, where I expanded my repertoire of experimental techniques to include those of a neurophysiology laboratory, examining the role of NMDA receptor subunit function in early synaptic development.
Meaghan Paganelli, PhD
B.S. in Neuroscience, University of Rochester
Ph.D. in Neuroscience, University at Buffalo
My research interests focus on how pharmacological agents can deferentially modify neuronal properties, function, and synaptic plasticity. During my graduate career at the University at Buffalo I became fascinated by the NMDA receptor and my dissertation research focused on delineating the molecular mechanisms by which the local anesthetic bupivacaine inhibits NMDA receptor gating suggesting a potentially novel therapeutic approach to prevent and treat chronic pain. Looking to translate my knowledge of NMDA receptor biophysical properties to synaptic biology, I joined Dr. John Gray’s to investigate the role of the NMDA receptor co-agonist glycine site in neurodevelopment, synaptic function, and plasticity with the long term goal of understanding how to target this site to reverse many NMDA receptor-mediated disorders. In my free time I enjoy traveling, hiking, soaking up the California sun, attending concerts, and spending time with my friends and family.
Jonathan Wong - Neuroscience Graduate Group
B.S. in Biochemistry and Spanish, Calvin College, Grand Rapids, MI
Memory is fundamental to the human experience and results from dynamic structural and biophysical changes between individual brain cells. Memory-altering illnesses are thought to disrupt these dynamic processes and preferentially decrease communication between cells. My project investigates newly characterized functions of the NMDA receptor which influence synaptic depression and how these functions might lead to the onset of Alzheimer's disease. Outside of the lab, you can find me engrossed in urban planning and architecture, tending my chickens, and touring by bicycle, backpack, motorbike, or canoe.
Eden Barragan - Neuroscience Graduate Group
B.S. in Biological Sciences, University of California, Irvine
I am a graduate student in the Neuroscience program here at Davis. I joined the Gray Lab in 2016 after graduating from UC Irvine. My research interests involve investigating the role of the NMDA receptor in synaptic plasticity and development. In my spare time I enjoy binge watching TV, running, pretending I am a photographer and hanging out with friends.
I am a third year Genetics and Spanish Major at UC Davis. My research interests center around the study of neurological diseases. After I complete undergrad I hope to enter medical school or continue to study genetics in a graduate level program. In my free time I enjoying traveling, running, and spending time with my friends and family.
Zaiyang "Sunny" Zhang
I am a third-year Neurobiology, Physiology, and Behavior (NPB) major, and my research interests focus on the cellular and molecular mechanisms behind neurodegenerative and psychotic diseases, especially ones involving memory dysfunction such as Alzheimer’s disease and Schizophrenia. Currently, I am helping with projects in the lab examining the functional and structural characteristics of NMDA Receptors that regulation LTP and LTD. I also have a strong interest in integrative medicine and am an active member of the UC Davis Western Equestrian Team.
Staff Research Associate